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Given the diversity of cell types in the mammalian brain, certain genomic loci may exhibit bipolar DNA methylation pattern, meaning that these loci are hypermethylated in some cell subtypes and hypomethylated in others, reflecting the functional diversity across different cell populations (Sun et al., 2016)

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They recruited 81 people from the Johns Hopkins Schizophrenia Center within 24 months of their first psychosis episode, which can be a characteristic symptom of schizophrenia, as well as 91 healthy controls from the community